Postoperative cognitive dysfunction after robot-assisted radical cystectomy (RARC) with cerebral oxygen monitoring an observational prospective cohort pilot study.

ABSTRACT: BACKGROUND:The incidence and risk factors of postoperative cognitive dysfunction (POCD) during robot-assisted radical cystectomy (RARC) in extreme Trendelenburg positioning and pneumoperitoneum are still controversial. The aim of this prospective observational study was to find the incidence rate as well as possible risk factors of POCD in RARC with cerebral oxygen monitoring. METHODS:Patients who underwent RARC and open abdominal surgery in horizontal positioning were included. Preoperative and postoperative arterial blood gas (ABG), S-100?, C-reactive protein (CRP), and cognitive dysfunction scales were tested. Also, we used Z score to analyze and comprehensively evaluate POCD. Measurements of heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), end-tidal CO2 (etCO2), and cerebral oxygen were immediately obtained after different time points during the surgery. RESULTS:Here, 24 and 23 patients were included in the RARC group and in the control group, respectively. The incidence of POCD didn't have significant difference in RARC group (45.8%), in contrast to the control group (26.1%). The laboratory tests of s100? and CRP between two groups didn't contain significant difference as well. As duration of Trendelenburg and pneumoperitoneum prolonged, the cerebral oxygen saturation in the RARC group increased, which didn't cause excessive perfusion nevertheless (rSO2<75%). We compared laboratory tests, age, education status, blood loss, and fluid input between POCD and non-POCD patients. A significant difference was found in the serum concentrations of CRP (72.59?±?42.09 vs. 48.50?±?26.53, P =?0.025) and age (69.20?±?7.033 vs. 65.34?±?5.228, P =?0.041). CONCLUSION:RARC in extreme Trendelenburg positioning and pneumoperitoneum did not significantly increase the incidence of POCD and didn't cause excessive perfusion. The inflammation marker CRP and age might be independent risk factors of POCD. TRIAL REGISTRATION:Clinicaltrials.gov with registration number NCT03372135 . Registered 1 November 2017 (retrospectively registered).

SUBMITTER: Li Y 

PROVIDER: S-EPMC6833280 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature