Ontology highlight
ABSTRACT:
SUBMITTER: Ebenezer DL
PROVIDER: S-EPMC6834354 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Ebenezer David L DL Berdyshev Evgeny V EV Bronova Irina A IA Liu Yuru Y Tiruppathi Chinnaswamy C Komarova Yulia Y Benevolenskaya Elizaveta V EV Suryadevara Vidyani V Ha Alison W AW Harijith Anantha A Tuder Rubin M RM Natarajan Viswanathan V Fu Panfeng P
Thorax 20190205 6
<h4>Introduction</h4>Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes expression.<h4>Methods</h4>Profile of sphingolipid species in bronchoalveolar lavage fluids and lung tissue of mice challenged with <i>Pseudomonas aeruginosa</i> (<i>PA</i>) was investigated. The role of nuclear sphingosine kinase (S ...[more]