Ontology highlight
ABSTRACT:
SUBMITTER: Hughes TE
PROVIDER: S-EPMC6834369 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Hughes Taylor Et TE Del Rosario John Smith JS Kapoor Abhijeet A Yazici Aysenur Torun AT Yudin Yevgen Y Fluck Edwin C EC Filizola Marta M Rohacs Tibor T Moiseenkova-Bell Vera Y VY
eLife 20191025
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe the contribution of TRPV5 in disease phenotypes such as hypercalcemia and nephrolithiasis. Here, we performed structure-based virtual screening (SBVS) at a previously identified TRPV5 inhibitor binding site coupled with electrophysiology screening and ...[more]