Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia.
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ABSTRACT:
SUBMITTER: Zhou D
PROVIDER: S-EPMC6834423 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Sirtuin 3 attenuates neuroinflammation-induced apoptosis in BV-2 microglia.
Zhou Dingzhou D Jiang Yugang Y
Aging 20191020 20
In this study, we explored the upstream regulatory mechanisms underlying inflammation-induced mitochondrial dysfunction in microglial BV-2 cells. Our results demonstrate that Sirtuin 3 (Sirt3) expression was downregulated in response to LPS-induced neuroinflammation. In addition, overexpression of Sirt3 attenuated LPS-induced BV-2 cell death. Functional studies illustrated that Sirt3 overexpression promoted normal mitochondrial function and inhibited mitochondria-dependent apoptosis in LPS-treat ...[more]
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