Unknown

Dataset Information

0

Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer.


ABSTRACT: Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

SUBMITTER: Nishio N 

PROVIDER: S-EPMC6834597 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications


Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the i  ...[more]

Similar Datasets

| S-EPMC6811564 | biostudies-literature
| S-EPMC6921159 | biostudies-literature
| S-EPMC4105535 | biostudies-literature
| S-EPMC9686335 | biostudies-literature
| S-EPMC5594659 | biostudies-literature
| S-EPMC4405778 | biostudies-literature
| S-EPMC10726506 | biostudies-literature
| S-EPMC10365081 | biostudies-literature
| S-EPMC5058361 | biostudies-literature
| S-EPMC2813735 | biostudies-literature