DJ-1 is dispensable for human stem cell homeostasis.
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ABSTRACT:
SUBMITTER: Cheng F
PROVIDER: S-EPMC6834734 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
DJ-1 is dispensable for human stem cell homeostasis.
Cheng Fang F Wang Si S Song Moshi M Liu Zunpeng Z Liu Ping P Wang Lei L Wang Yanjiang Y Zhao Qian Q Yan Kaowen K Chan Piu P Zhang Weiqi W Qu Jing J Liu Guang-Hui GH
Protein & cell 20191101 11
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Project description:our data showed that the absence of DJ-1 had no adverse effects on proliferation, differentiation, and oxidative stress responses of human stem cells such as hNSCs and hMSCs as well as hVECs, suggesting that loss of DJ-1 function alone is insufficient to disrupt the homeostasis of these human cells. In addition, we found that CHCHD2 was upregulated upon DJ-1 deficiency, which may account for the absence of severe phenotypes in various types of DJ-1-deficient cells. For the first time, our study revealed the 'see-saw' expression pattern of two Parkinson’s disease-associated genes, providing potential clues for understanding the mechanisms of DJ-1- and CHCHD2-associated Parkinson’s disease.
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Project description:DJ-1 is dispensable for human stem cell homeostasis
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