Ontology highlight
ABSTRACT:
SUBMITTER: Cartuche L
PROVIDER: S-EPMC6836125 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cartuche Luis L Reyes-Batlle María M Sifaoui Ines I Arberas-Jiménez Iñigo I Piñero José E JE Fernández José J JJ Lorenzo-Morales Jacob J Díaz-Marrero Ana R AR
Marine drugs 20191017 10
Indolocarbazoles are a family of natural alkaloids characterized by their potent protein kinase and topoisomerase I inhibitory activity. Among them, staurosporine (<b>1</b>) has exhibited promising inhibitory activity against parasites. Based on new insights on the activity and mechanism of action of STS in <i>Acanthamoeba</i> parasites, this work reports the isolation, identification, and the anti-<i>Acanthamoeba</i> activity of the minor metabolites 7-oxostaurosporine (<b>2</b>), 4'-demethylam ...[more]