Ontology highlight
ABSTRACT:
SUBMITTER: Rajbhandari P
PROVIDER: S-EPMC6837845 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Rajbhandari Prashant P Arneson Douglas D Hart Sydney K SK Ahn In Sook IS Diamante Graciel G Santos Luis C LC Zaghari Nima N Feng An-Chieh AC Thomas Brandon J BJ Vergnes Laurent L Lee Stephen D SD Rajbhandari Abha K AK Reue Karen K Smale Stephen T ST Yang Xia X Tontonoz Peter P
eLife 20191023
Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to be defined. We demonstrate here that selective loss of IL10 receptor α in adipocytes recapitulates the beneficial effects of global IL10 deletion, and that local crosstalk between IL10-producing immune cells and adipocytes is a determinant of ther ...[more]