Ontology highlight
ABSTRACT:
SUBMITTER: Alseth EO
PROVIDER: S-EPMC6837874 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Alseth Ellinor O EO Pursey Elizabeth E Luján Adela M AM McLeod Isobel I Rollie Clare C Westra Edze R ER
Nature 20191023 7779
About half of all bacteria carry genes for CRISPR-Cas adaptive immune systems<sup>1</sup>, which provide immunological memory by inserting short DNA sequences from phage and other parasitic DNA elements into CRISPR loci on the host genome<sup>2</sup>. Whereas CRISPR loci evolve rapidly in natural environments<sup>3,4</sup>, bacterial species typically evolve phage resistance by the mutation or loss of phage receptors under laboratory conditions<sup>5,6</sup>. Here we report how this discrepancy ...[more]