Ontology highlight
ABSTRACT:
SUBMITTER: Borges AL
PROVIDER: S-EPMC7190418 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Borges Adair L AL Castro Bardo B Govindarajan Sutharsan S Solvik Tina T Escalante Veronica V Bondy-Denomy Joseph J
Nature microbiology 20200323 5
CRISPR-Cas systems are adaptive immune systems that protect bacteria from bacteriophage (phage) infection<sup>1</sup>. To provide immunity, RNA-guided protein surveillance complexes recognize foreign nucleic acids, triggering their destruction by Cas nucleases<sup>2</sup>. While the essential requirements for immune activity are well understood, the physiological cues that regulate CRISPR-Cas expression are not. Here, a forward genetic screen identifies a two-component system (KinB-AlgB), previo ...[more]