Ontology highlight
ABSTRACT:
SUBMITTER: Loi M
PROVIDER: S-EPMC6838186 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Loi Marisa M Raimondi Andrea A Morone Diego D Molinari Maurizio M
Nature communications 20191107 1
The endoplasmic reticulum (ER) produces about 40% of the nucleated cell's proteome. ER size and content in molecular chaperones increase upon physiologic and pathologic stresses on activation of unfolded protein responses (UPR). On stress resolution, the mammalian ER is remodeled to pre-stress, physiologic size and function on activation of the LC3-binding activity of the translocon component SEC62. This elicits recov-ER-phagy, i.e., the delivery of the excess ER generated during the phase of st ...[more]