Ontology highlight
ABSTRACT:
SUBMITTER: Hubner CA
PROVIDER: S-EPMC7206075 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hübner Christian A CA Dikic Ivan I
Cell death and differentiation 20191028 3
Autophagy regulates the degradation of unnecessary or dysfunctional cellular components. This catabolic process requires the formation of a double-membrane vesicle, the autophagosome, that engulfs the cytosolic material and delivers it to the lysosome. Substrate specificity is achieved by autophagy receptors, which are characterized by the presence of at least one LC3-interaction region (LIR) or GABARAP-interaction motif (GIM). Only recently, several receptors that mediate the specific degradati ...[more]