Ontology highlight
ABSTRACT:
SUBMITTER: Islam MN
PROVIDER: S-EPMC6839046 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Islam Md Nurul MN Mita Yuichiro Y Maruyama Keisuke K Tanida Ryota R Zhang Weidong W Sakoda Hideyuki H Nakazato Masamitsu M
The Journal of endocrinology 20200101 1
Ghrelin, a stomach-derived peptide, promotes feeding and growth hormone (GH) secretion. A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous inhibitor of ghrelin-induced GH secretion, but the effect of LEAP2 in the brain remained unknown. In this study, we showed that intracerebroventricular (i.c.v.) administration of LEAP2 to rats suppressed central ghrelin functions including Fos expression in the hypothalamic nuclei, promotion of food intake, blood glucos ...[more]