Ontology highlight
ABSTRACT:
SUBMITTER: Penela P
PROVIDER: S-EPMC6841920 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Penela Petronila P Ribas Catalina C Sánchez-Madrid Francisco F Mayor Federico F
Cellular and molecular life sciences : CMLS 20190820 22
Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a versatile protein that acts as a signaling hub by modulating G protein-coupled receptor (GPCR) signaling and also via phosphorylation or scaffolding interactions with an extensive number of non-GPCR cellular partners. GRK2 multifunctionality arises from its multidomain structure and from complex mechanisms of regulation of its expression levels, activity, and localization within the cell, what allows the precise ...[more]