Ontology highlight
ABSTRACT:
SUBMITTER: Longo V
PROVIDER: S-EPMC6843273 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Longo Vito V Brunetti Oronzo O Gnoni Antonio A Licchetta Antonella A Delcuratolo Sabina S Memeo Riccardo R Solimando Antonio Giovanni AG Argentiero Antonella A
Medicina (Kaunas, Lithuania) 20191017 10
Hepatocellular carcinoma is the most common primary liver cancer and the fourth leading cause of cancer death worldwide. A total of 70-80% of patients are diagnosed at an advanced stage with a dismal prognosis. Sorafenib had been the standardcare for almost a decade until 2018 when the Food and Drug Administration approved an alternative first-line agent namely lenvatinib. Cabozantinib, regorafenib, and ramucirumab also displayed promising results in second line settings. FOLFOX4, however, resul ...[more]