Dataset Information

Characterization of Airborne Particles Emitted During Application of Cosmetic Talc Products.

ABSTRACT: A pilot study was undertaken to characterize the concentration, duration and particle size distribution of the talc cloud that forms in the personal breathing zone (PBZ) during application of certain talc-containing cosmetics. Multiple direct-reading instruments were employed to simultaneously monitor PM4 concentrations (particulate matter with aerodynamic diameter < 4 µm; mg/m3) at different distances from each of three subjects while they applied talc products. Results indicated that the purpose and method of applying the talc product, combined with behavioral and physical differences amongst subjects, all strongly influenced airborne talc concentrations and the duration of the cloud. Air concentrations of talc in the PBZ averaged around 1.0 mg/m3, and the duration of exposure varied from less than one minute to more than ten minutes. The real-time monitors captured the occasional formation of secondary clouds, likely caused by resuspension of talc particles from skin or other surfaces. Measurements of aerosolized baby powder, face powder, and two adult body powders indicated that the median aerodynamic diameter of the talc cloud ranged from 1.7 to 2.0 µm. These direct-reading approaches were valuable for providing detailed characterization of short duration exposures to airborne talc particles, and will be useful to support future exposure assessments of talc and other powders in consumer products.

SUBMITTER: Rasmussen PE

PROVIDER: S-EPMC6843753 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Characterization of Airborne Particles Emitted During Application of Cosmetic Talc Products.

Rasmussen Pat E PE Levesque Christine C Niu Jianjun J Gardner Howard D HD Nilsson Gregory G Macey Kristin K

International journal of environmental research and public health 20191011 20

A pilot study was undertaken to characterize the concentration, duration and particle size distribution of the talc cloud that forms in the personal breathing zone (PBZ) during application of certain talc-containing cosmetics. Multiple direct-reading instruments were employed to simultaneously monitor PM<sub>4</sub> concentrations (particulate matter with aerodynamic diameter < 4 µm; mg/m<sup>3</sup>) at different distances from each of three subjects while they applied talc products. Results in ...[more]

PMID: 31614435

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Project description:Background:No systematic investigations have been conducted to assess the lung burden imposed by the chronic inhalation of silver nanoparticles (AgNPs) emitted by spray products. Objective:The objective of this study was to formulate a study framework that integrates a probabilistic risk assessment scheme with a mechanistic lung burden model for the estimation of health risks associated with the long-term inhalation of AgNP-containing spray products. Materials and methods:A compartmentalized physiologically based alveolar deposition (PBAD) model was used to estimate AgNP lung burden. Dose-response relationships were established using nanotoxicity data sets obtained from rats (as a model organism). Weibull model-based thresholds of AgNP lung burden based on neutrophil-elevated inflammation bio-markers were estimated from Hill-based exposure-response relationships. Finally, the risks of lung disease posed by various AgNP-containing spray products were assessed. Results:Conservative thresholds for the prevention of pulmonary disease were estimated as follows (mean ± SE): 34 nm AgNPs (0.32±0.22 mg) and 60 nm AgNPs (1.08±0.64 mg). Our results indicate that the risk probability was ~0.5 that the hazard quotient (HQ) estimates of deodorant with a count median diameter (CMD) ≈30 nm exceeded 1. The primary risk posed by AgNPs is transferred from the interstitial region to lymph nodes. Under the condition of 50% risk probability, the 97.5 percentile of HQ for the spray products were as follows: CMD ≈30 nm (~3.4) and CMD ≈60 nm (~1.1). Conclusion:Our application of the proposed risk assessment scheme to the results obtained in an in vivo animal model proved highly effective in elucidating the relationship between the characteristics of metallic NP-containing spray products and their corresponding toxicity. The integration of the proposed PBAD model with a risk assessment framework enables the rapid assessment of risk posed by spray products containing metallic NPs over various time scales.

Dataset Information

Characterization of Airborne Particles Emitted During Application of Cosmetic Talc Products.

Publications

Characterization of Airborne Particles Emitted During Application of Cosmetic Talc Products.

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