Ontology highlight
ABSTRACT:
SUBMITTER: Wang N
PROVIDER: S-EPMC6844090 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
ACS omega 20191028 19
For decades, the dye 8-anilino-1-naphthalenesulfonic acid (ANS) has been used to study biological systems due to its environmentally sensitive fluorescent nature and propensity to bind to hydrophobic pockets of proteins. However, the syntheses of ANS and its derivatives have been low yielding, requiring harsh reaction conditions and long reaction times. We have developed efficient, mild microwave-assisted copper(0)-catalyzed Ullmann coupling conditions to synthesize ANS derivatives with yields o ...[more]