Ontology highlight
ABSTRACT:
SUBMITTER: Daniel J
PROVIDER: S-EPMC6844107 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Daniel Jonathan J Montaleytang Maeva M Nagarajan Sounderya S Picard Sébastien S Clermont Guillaume G Lazar Adina N AN Dumas Noé N Correard Florian F Braguer Diane D Blanchard-Desce Mireille M Estève Marie-Anne MA Vaultier Michel M
ACS omega 20191024 19
Highly water-soluble, nontoxic organic nanoparticles on which paclitaxel (PTX), a hydrophobic anticancer drug, has been covalently bound via an ester linkage (4.5% of total weight) have been prepared for the treatment of glioblastoma. These soft fluorescent organic nanoparticles (FONPs), obtained from citric acid and diethylenetriamine by microwave-assisted condensation, show suitable size (Ø = 17-30 nm), remarkable solubility in water, softness as well as strong blue fluorescence in an aqueous ...[more]