Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK Biobank.
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ABSTRACT:
SUBMITTER: Cordova-Palomera A
PROVIDER: S-EPMC6848143 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Association between the 4p16 genomic locus and different types of congenital heart disease: results from adult survivors in the UK Biobank.
Córdova-Palomera Aldo A Priest James R JR
Scientific reports 20191111 1
Congenital heart disease is the most common birth defect in newborns and the leading cause of death in infancy, affecting nearly 1% of live births. A locus in chromosome 4p16, adjacent to MSX1 and STX18, has been associated with atrial septal defects (ASD) in multiple European and Chinese cohorts. Here, genotyping data from the UK Biobank was used to test for associations between this locus and congenital heart disease in adult survivors of left ventricular outflow tract obstruction (n = 164) an ...[more]
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