Ontology highlight
ABSTRACT:
SUBMITTER: Nicol B
PROVIDER: S-EPMC6848188 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191111 1
Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the supporting cell lineage and becomes pre-granulosa cell-specific as the gonads differentiate. ...[more]