White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions.
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ABSTRACT:
SUBMITTER: Stiso J
PROVIDER: S-EPMC6849479 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
White Matter Network Architecture Guides Direct Electrical Stimulation through Optimal State Transitions.
Stiso Jennifer J Khambhati Ankit N AN Menara Tommaso T Kahn Ari E AE Stein Joel M JM Das Sandihitsu R SR Gorniak Richard R Tracy Joseph J Litt Brian B Davis Kathryn A KA Pasqualetti Fabio F Lucas Timothy H TH Bassett Danielle S DS
Cell reports 20190901 10
Optimizing direct electrical stimulation for the treatment of neurological disease remains difficult due to an incomplete understanding of its physical propagation through brain tissue. Here, we use network control theory to predict how stimulation spreads through white matter to influence spatially distributed dynamics. We test the theory's predictions using a unique dataset comprising diffusion weighted imaging and electrocorticography in epilepsy patients undergoing grid stimulation. We find ...[more]
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