The effects of direct brain stimulation in humans depend on frequency, amplitude, and white-matter proximity.

ABSTRACT:

Background

Researchers have used direct electrical brain stimulation to treat a range of neurological and psychiatric disorders. However, for brain stimulation to be maximally effective, clinicians and researchers should optimize stimulation parameters according to desired outcomes.

Objective

The goal of our large-scale study was to comprehensively evaluate the effects of stimulation at different parameters and locations on neuronal activity across the human brain.

Methods

To examine how different kinds of stimulation affect human brain activity, we compared the changes in neuronal activity that resulted from stimulation at a range of frequencies, amplitudes, and locations with direct human brain recordings. We recorded human brain activity directly with electrodes th

SUBMITTER: Mohan UR 

PROVIDER: S-EPMC7494653 | biostudies-literature | 2020 Sep - Oct

REPOSITORIES: biostudies-literature