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Photoredox-catalyzed stereoselective alkylation of enamides with N-hydroxyphthalimide esters via decarboxylative cross-coupling reactions.
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ABSTRACT:
SUBMITTER: Guo JY
PROVIDER: S-EPMC6849636 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Publications
Photoredox-catalyzed stereoselective alkylation of enamides with <i>N</i>-hydroxyphthalimide esters <i>via</i> decarboxylative cross-coupling reactions.
Chemical science 20190805 38
Stereoselective β-C(sp<sup>2</sup>)-H alkylation of enamides with redox-active <i>N</i>-hydroxyphthalimide esters <i>via</i> a photoredox-catalyzed decarboxylative cross-coupling reaction is demonstrated. This methodology features operational simplicity, broad substrate scopes, and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory ...[more]