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Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters.

ABSTRACT: An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively trans to the substituent present on the dihydropyridone ring affording stereochemical control about the new carbon-carbon bond. These reactions are operationally simplistic and afford the desired products in good to excellent isolated yields.

SUBMITTER: Dykstra K

PROVIDER: S-EPMC8777773 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters.

Dykstra Kevin K Buevich Alexei A Gao Qi Q Lam Yu-Hong YH Kuethe Jeffrey T JT

Molecules (Basel, Switzerland) 20220110 2

An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively <i>trans</i> to the substituent present on the dihydropyridone ring affording stereochemical control about the new carbon-carbon bond. These reactions are operationally simplistic and afford the desired products in good to excellent isolated yields. ...[more]

PMID: 35056732

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