Ontology highlight
ABSTRACT:
SUBMITTER: Rennella E
PROVIDER: S-EPMC6850217 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rennella Enrico E Morgan Gareth J GJ Yan Nicholas N Kelly Jeffery W JW Kay Lewis E LE
Journal of the American Chemical Society 20190814 34
Immunoglobulin light-chain amyloidosis is a protein aggregation disease that leads to proteinaceous deposits in a variety of organs in the body and, if untreated, ultimately results in death. The mechanisms by which light-chain aggregation occurs are not well understood. Here we have used solution NMR spectroscopy and biophysical studies to probe immunoglobulin variable domain λV6-57 V<sub>L</sub> aggregation, a process that appears to drive the degenerative phenotypes in amyloidosis patients. O ...[more]