Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice.
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ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC6850426 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Postnatal nectin-3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice.
Liu Rui R Wang Han H Wang Hong-Li HL Sun Ya-Xin YX Su Yun-Ai YA Wang Xiao-Dong XD Li Ji-Tao JT Si Tian-Mei TM
Hippocampus 20190508 11
The early postnatal stage is a critical period of hippocampal neurodevelopment and also a period of high vulnerability to adverse life experiences. Recent evidence suggests that nectin-3, a cell adhesion molecule, mediates memory dysfunction and dendritic alterations in the adult hippocampus induced by postnatal stress. But it is unknown whether postnatal nectin-3 reduction alone is sufficient to alter hippocampal structure and function in adulthood. Here, we down regulated hippocampal expressio ...[more]
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