Unknown

Dataset Information

0

Building de novo cryo-electron microscopy structures collaboratively with citizen scientists.

ABSTRACT: With the rapid improvement of cryo-electron microscopy (cryo-EM) resolution, new computational tools are needed to assist and improve upon atomic model building and refinement options. This communication demonstrates that microscopists can now collaborate with the players of the computer game Foldit to generate high-quality de novo structural models. This development could greatly speed the generation of excellent cryo-EM structures when used in addition to current methods.

SUBMITTER: Khatib F 

PROVIDER: S-EPMC6850521 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Building de novo cryo-electron microscopy structures collaboratively with citizen scientists.

Khatib Firas F   Desfosses Ambroise A   Koepnick Brian B   Flatten Jeff J   Popović Zoran Z   Baker David D   Cooper Seth S   Gutsche Irina I   Horowitz Scott S  

PLoS biology 20191112 11

With the rapid improvement of cryo-electron microscopy (cryo-EM) resolution, new computational tools are needed to assist and improve upon atomic model building and refinement options. This communication demonstrates that microscopists can now collaborate with the players of the computer game Foldit to generate high-quality de novo structural models. This development could greatly speed the generation of excellent cryo-EM structures when used in addition to current methods. ...[more]

Similar Datasets

Unknown De novo protein design by citizen scientists.
| S-EPMC6701466 | biostudies-literature
Unknown Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design.
| S-EPMC3421226 | biostudies-literature
Unknown De novo modeling of the F(420)-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy.
| S-EPMC3591093 | biostudies-literature
Unknown Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions.
| S-EPMC4304694 | biostudies-literature
Unknown Cryo-Electron Microscopy Structures of the <i>Pneumoviridae</i> Polymerases.
| S-EPMC8020502 | biostudies-literature
Unknown Near-atomic cryo-electron microscopy structures of varicella-zoster virus capsids.
| S-EPMC7677223 | biostudies-literature
Unknown Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
| S-EPMC5795435 | biostudies-literature
Unknown Building flux capacity: Citizen scientists increase resolution of soil greenhouse gas fluxes.
| S-EPMC6033390 | biostudies-literature
Unknown Detection of secondary and supersecondary structures of proteins from cryo-electron microscopy.
| S-EPMC3312805 | biostudies-literature
Unknown Tools for Model Building and Optimization into Near-Atomic Resolution Electron Cryo-Microscopy Density Maps.
| S-EPMC5103630 | biostudies-literature