Cryo-Electron Microscopy Structures of the Pneumoviridae Polymerases.
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ABSTRACT: The resolution revolution of cryo-electron microscopy (cryo-EM) has made a significant impact on the structural analysis of the Pneumoviridae multifunctional RNA polymerases. In recent months, several high-resolution structures of apo RNA polymerases of Pneumoviridae, which includes the human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV), have been determined by single-particle cryo-EM. These structures illustrated high similarities and minor differences between the Pneumoviridae polymerases and revealed the potential mechanisms of the Pneumoviridae RNA synthesis.
SUBMITTER: Cao D
PROVIDER: S-EPMC8020502 | biostudies-literature |
REPOSITORIES: biostudies-literature
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