Ontology highlight
ABSTRACT:
SUBMITTER: Haraguchi S
PROVIDER: S-EPMC6850767 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Haraguchi Shogo S Kamata Masaki M Tokita Takuma T Tashiro Kei-Ichiro KI Sato Miku M Nozaki Mitsuki M Okamoto-Katsuyama Mayumi M Shimizu Isao I Han Guofeng G Chowdhury Vishwajit Sur VS Lei Xiao-Feng XF Miyazaki Takuro T Kim-Kaneyama Joo-Ri JR Nakamachi Tomoya T Matsuda Kouhei K Ohtaki Hirokazu H Tokumoto Toshinobu T Tachibana Tetsuya T Miyazaki Akira A Tsutsui Kazuyoshi K
eLife 20190930
The molecular mechanisms by which environmental light conditions affect cerebellar development are incompletely understood. We showed that circadian disruption by light-at-night induced Purkinje cell death through pineal allopregnanolone (ALLO) activity during early life in chicks. Light-at-night caused the loss of diurnal variation of pineal ALLO synthesis during early life and led to cerebellar Purkinje cell death, which was suppressed by a daily injection of ALLO. The loss of diurnal variatio ...[more]