Ontology highlight
ABSTRACT:
SUBMITTER: Fleming CL
PROVIDER: S-EPMC6851755 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Fleming Cassandra L CL Sandoz Patrick A PA Inghardt Tord T Önfelt Björn B Grøtli Morten M Andréasson Joakim J
Angewandte Chemie (International ed. in English) 20190905 42
The development of a fluorescent LCK inhibitor that exhibits favourable solvatochromic properties upon binding the kinase is described. Fluorescent properties were realised through the inclusion of a prodan-derived fluorophore into the pharmacophore of an ATP-competitive kinase inhibitor. Fluorescence titration experiments demonstrate the solvatochromic properties of the inhibitor, in which dramatic increase in emission intensity and hypsochromic shift in emission maxima are clearly observed upo ...[more]