Ontology highlight
ABSTRACT:
SUBMITTER: Qian J
PROVIDER: S-EPMC6853080 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Chemical science 20190807 38
Reported is a unique chemoselectivity approach to base-promoted defluorinative and Cu(i)-catalyzed aerobic oxidative non-defluorinative [5 + 1] condensation aromatizations of simple unsaturated ketones with ammonium salts <i>via</i> Meisenheimer-type nitrogen anion and radical intermediates. The CuBr/O<sub>2</sub> catalysis provides a straightforward approach to diverse 3-fluoropyridines in high yields. The synthetic utility of the strategy is highlighted by the concise synthesis of several F-mo ...[more]