Dataset Information

Associations of long-term exposure to PM1, PM2.5, NO2 with type 2 diabetes mellitus prevalence and fasting blood glucose levels in Chinese rural populations.

ABSTRACT: OBJECTIVES:To evaluate the associations between long-term exposure to particulate matter with an aerodynamic diameter ?1.0??m and ?2.5??m (PM1 and PM2.5), nitrogen dioxide (NO2) and type 2 diabetes prevalence and fasting blood glucose levels in Chinese rural populations. MATERIAL AND METHODS:A total of 39, 259 participants were enrolled in The Henan Rural Cohort study. Questionnaires and medical examination were conducted from July 2015 to September 2017 in rural areas of Henan province, China. Three-year average residential exposure levels of PM1, PM2.5, NO2 for each subject were estimated by a spatiotemporal model. Logistic regression and linear regression models were applied to estimate the associations between PM1, PM2.5, NO2 exposure and type 2 diabetes prevalence and fasting blood glucose levels. RESULTS:The mean 3-year residential exposure concentrations of PM1, PM2.5 and NO2 was 57.4??g/m3, 73.4??g/m3 and 39.9??g/m3, respectively. Higher exposure concentrations of PM1, PM2.5, NO2 by 1??g/m3 was positively related to a 4.0% (95%CIs: 1.026, 1.054), 6.8% (1.052, 1.084) and 5.0% (1.039, 1.061) increase in odds of type 2 diabetes in the final adjusted models. Besides, a 1??g/m3 increase of PM1, PM2.5 and NO2 was related to a 0.020?mmol/L (95%CIs: 0.014, 0.026), 0.036?mmol/L (95%CIs: 0.030, 0.042) and 0.030?mmol/L (95%CIs: 0.026, 0.034) mmol/L higher fasting blood glucose levels. CONCLUSIONS:Higher exposure concentrations of air pollutants were positively related to the increased odds of type 2 diabetes, as well as higher fasting blood glucose levels in Chinese rural populations.

SUBMITTER: Liu F

PROVIDER: S-EPMC6853163 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Associations of long-term exposure to PM<sub>1</sub>, PM<sub>2.5</sub>, NO<sub>2</sub> with type 2 diabetes mellitus prevalence and fasting blood glucose levels in Chinese rural populations.

Liu Feifei F Guo Yuming Y Liu Yisi Y Chen Gongbo G Wang Yuxin Y Xue Xiaowei X Liu Suyang S Huo Wenqian W Mao Zhenxing Z Hou Yitan Y Lu Yuanan Y Wang Chongjian C Xiang Hao H Li Shanshan S

Environment international 20191022 Pt B

<h4>Objectives</h4>To evaluate the associations between long-term exposure to particulate matter with an aerodynamic diameter ≤1.0 μm and ≤2.5 μm (PM<sub>1</sub> and PM<sub>2.5</sub>), nitrogen dioxide (NO<sub>2</sub>) and type 2 diabetes prevalence and fasting blood glucose levels in Chinese rural populations.<h4>Material and methods</h4>A total of 39, 259 participants were enrolled in The Henan Rural Cohort study. Questionnaires and medical examination were conducted from July 2015 to Septembe ...[more]

PMID: 31654916

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Project description:BACKGROUND:The extent to which diabetes mellitus or hyperglycemia is related to risk of death from cancer or other nonvascular conditions is uncertain. METHODS:We calculated hazard ratios for cause-specific death, according to baseline diabetes status or fasting glucose level, from individual-participant data on 123,205 deaths among 820,900 people in 97 prospective studies. RESULTS:After adjustment for age, sex, smoking status, and body-mass index, hazard ratios among persons with diabetes as compared with persons without diabetes were as follows: 1.80 (95% confidence interval [CI], 1.71 to 1.90) for death from any cause, 1.25 (95% CI, 1.19 to 1.31) for death from cancer, 2.32 (95% CI, 2.11 to 2.56) for death from vascular causes, and 1.73 (95% CI, 1.62 to 1.85) for death from other causes. Diabetes (vs. no diabetes) was moderately associated with death from cancers of the liver, pancreas, ovary, colorectum, lung, bladder, and breast. Aside from cancer and vascular disease, diabetes (vs. no diabetes) was also associated with death from renal disease, liver disease, pneumonia and other infectious diseases, mental disorders, nonhepatic digestive diseases, external causes, intentional self-harm, nervous-system disorders, and chronic obstructive pulmonary disease. Hazard ratios were appreciably reduced after further adjustment for glycemia measures, but not after adjustment for systolic blood pressure, lipid levels, inflammation or renal markers. Fasting glucose levels exceeding 100 mg per deciliter (5.6 mmol per liter), but not levels of 70 to 100 mg per deciliter (3.9 to 5.6 mmol per liter), were associated with death. A 50-year-old with diabetes died, on average, 6 years earlier than a counterpart without diabetes, with about 40% of the difference in survival attributable to excess nonvascular deaths. CONCLUSIONS:In addition to vascular disease, diabetes is associated with substantial premature death from several cancers, infectious diseases, external causes, intentional self-harm, and degenerative disorders, independent of several major risk factors. (Funded by the British Heart Foundation and others.).

Project description:BACKGROUND:This study uses bibliometric analysis to describe the state of research about the association of NO2, PM2.5 and noise exposures - three traffic-related pollutants - with cardiometabolic disorders. METHODS:We retrieved references published 1994-2017 from Scopus and classified references with respect to exposure, health outcome and study design using index keywords. Temporal trend, top cited references, used index keywords and the number of hypothesis testing and non-hypothesis testing study design for each group were identified. RESULTS:Results show PM2.5 is the most frequently studied exposure (47%), followed by both NO2 and PM2.5 exposure (29%). Only 3% of references considered multiple exposures between NO2 and/or PM2.5 and noise, and these were published after 2008. While we observed a growing trend in studies with NO2 and/or PM2.5 and noise and diabetes in the last decade, there is a diminishing trend in studies with noise and diabetes. Different patterns of study designs were found through H/NH ratio, the number of references classified as having a hypothesis (H)-testing design relative to the number of references classified as having a non-hypothesis (NH)-testing design. Studies with NO2 and/or PM2.5 exposure are more likely to have a H-testing design, while those with noise exposure are more likely to have a NH-testing design, such as cross-sectional study design. CONCLUSIONS:We conclude with three themes about research trends. First, the study of simultaneous exposures to multiple pollutants is a current trend, and likely to continue. Second, the association between traffic-related pollutants and diabetes and metabolic symptoms is an area for growth in research. Third, the transition to the use of H-testing study designs to explore associations between noise and cardiometabolic outcomes may be supported by improved understanding of the mechanism of action, and/or improvements to the accuracy and precision of air pollution and noise exposure assessments for environmental health research.

Dataset Information

Associations of long-term exposure to PM1, PM2.5, NO2 with type 2 diabetes mellitus prevalence and fasting blood glucose levels in Chinese rural populations.

Publications

Associations of long-term exposure to PM<sub>1</sub>, PM<sub>2.5</sub>, NO<sub>2</sub> with type 2 diabetes mellitus prevalence and fasting blood glucose levels in Chinese rural populations.

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