Ontology highlight
ABSTRACT:
SUBMITTER: Geiger F
PROVIDER: S-EPMC6853323 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Geiger Florian F Rüdiger Daniel D Zahler Stefan S Engelke Hanna H
PloS one 20191113 11
Cancer cell migration is influenced by cellular phenotype and behavior as well as by the mechanical and chemical properties of the environment. Furthermore, many cancer cells show plasticity of their phenotype and adapt it to the properties of the environment. Here, we study the influence of fiber stiffness, confinement, and adhesion properties on cancer cell migration in porous collagen gels. Collagen gels with soft fibers abrogate migration and promote a round, non-invasive phenotype. Stiffer ...[more]