Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mineralized collagen induces phenotypic changes in MDA-MB-231

ABSTRACT: We examine the transcriptional alterations induced by in vitro culture of MDA-MB-231 cells on microfabricated hydroxyapatite-mineralized collagen devices that simulate bone matrix (PMID 29759731). As a control, we additionally characterize the transcriptional activity of cells cultured on a collagen substrate. We find that mineralized collagen increases the expression of genes associated with stemness and metastasis while culture on collagen increased expression of genes associated with cell cycle progression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE229094 | GEO | 2023/07/19

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Mineralized collagen induces phenotypic changes in MDA-MB-231

Project description:Mineralized collagen induces phenotypic changes in MDA-MB-231

| PRJNA952893 | ENA

Collagen-GAG Biocompatibility Tests

Project description:All mRNA was isolated after 8 hours of culture time in each of three culture conditions. (1) TCPS Plate, (2) Collagen-GAG 2 dimensional coated plate and (3) collagen-GAG three dimensional mesh. Keywords: ordered

2004-11-09 | GSE1937 | GEO

Transcription profiling of human fibroblasts grown on TCPS plates, Collagen-GAG 2 D plate and Collagen-GAG 3D mesh

2008-06-11 | E-GEOD-1937 | biostudies-arrayexpress

Fibrillar collagen implicated in pregnancy-induced protection of mammary cancer

Project description:A suggested role for fibrillr collagen topology in the pregnancy-induced protection and invasive phenotype. Two conditions: RNA was isolated from murine mammary D2.OR cells cultured in fibrillar collagen I and non-fibrillar collagen I in 3D cell culture

2013-07-16 | E-GEOD-39539 | biostudies-arrayexpress

Collagen 1 Hydrogel Dynamic Loading Tests

Project description:Cell viability and global gene expression was anayzed from collagen 1 hydrogel scaffolds following 3 hours of cyclic mechanical loading and compared with non-loaded scaffolds. Keywords: human dermal fibroblasts; dynamic cell culture; mechanical stress

2008-01-11 | GSE10125 | GEO

Madin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.

Project description:In order to gain insight into epithelial morphogenesis and the influence of culture geometry on gene expression patterns, Madin Darby Canine Kidney (MDCK) epithelial cells where grown in 2-dimensional (2D) culture or 3-dimensional (3D) culture . MDCK cells cultured in 2D were plated atop a pre-solidified type I collagen gel. Cells cultured under these conditions grew as flat monolayer sheets. In 3D culture, cells are embedded within type I collagen gel. Cells grown under these conditions form large spherical cysts with hollow central lumens. We anticipate, therefore, that these results provide insight into the mechanisms that regulate epithelial cystogenesis.

2013-06-03 | GSE28381 | GEO

Gene expression in TNF treated rat aortic rings cultured in collagen or fibrin gels.

Project description:Angiogenesis in cultures of rat aorta begins with neovessels sprouting from the aortic explant within the first three days of culture. We used microarrys to examine the effects of TNF-alpha on gene expression in both fibrin and collagen gels during the first 48 hours or culture. Rat aortic rings were cultured in either collagen or fibrin maticies. Half of the cultures from each matrix group were treated with 10ng/ml recombinant rat TNF-alpha, and half were left untreated. These cultures were used to prepare total RNA

2011-07-20 | E-GEOD-23153 | biostudies-arrayexpress

Madin-Darby Canine Kidney (MDCK) cells grown in 2-dimensional and 3-dimensional type I collagen culture.

2013-06-03 | E-GEOD-28381 | biostudies-arrayexpress

Gene expression of rat PSCs cultured on plastic, matrigel and collagen

Project description:Activated pancreatic stellate cells produce the fibrotic matrix in chronic pancreatitis and pancreatic cancer. In vitro protocols examining PSC biology have usually involved PSCs cultured on plastic, a non-physiological surface. However, PSCs cultured on physiological matrices e.g. MatrigelTM (normal basement membrane) and collagen (fibrotic pancreas), may have distinctly different behaviours compared to cells cultured on plastic. Therefore, we aimed to compare PSC gene expression after culture on plastic, MatrigelTM and collagen I.

2013-01-17 | GSE43496 | GEO

Gene expression in TNF treated rat aortic rings cultured in collagen or fibrin gels.

2011-07-21 | GSE23153 | GEO