Dataset Information

Association Between Late Bedtime and Diabetes Mellitus: A Large Community-Based Study.

ABSTRACT: STUDY OBJECTIVES:The aim of this study was to investigate the association of bedtime with the prevalence of diabetes mellitus (DM) based on a large community-based population. METHODS:In total, 5,420 participants (2,574 males and 2,846 females; aged 63.5 ± 11.0 years) from the Sleep Heart Health Study database were selected in this study. Sleep habit was recorded based on a questionnaire administered to patients upon recruitment. Bedtime was categorized as 11:00?pm and before, 11:00?pm to 12:00?am, and 12:00?am and later in the current study. Multivariate logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) to determine the relationship between bedtime and the prevalence of DM. RESULTS:The distribution of weekday bedtime at 11:00?pm and before, 11:00?pm to 12:00?am, 12:00?am and later was observed in 3,316 participants (61.2%), 991 participants (18.3%), and 1,113 participants (20.5%), respectively. Meanwhile, individuals with weekday bedtime of 12:00?am and later had a higher prevalence of DM than those with bedtime at 11:00?pm to 12:00?am, and 11:00?pm and before (10.6% versus 5.7% versus 6.6%, respectively; P < .001). In the adjusted multivariate logistic regression model, bedtime at 12:00?am and later on a weekday was significantly associated DM prevalence (OR 1.446, 95% CI 1.107-1.888, P = .007). No significant association was found between weekend bedtime and DM. CONCLUSION:Late bedtime at 12:00?am and later on a weekday may be a risk factor for the prevalence of DM. Stable sleep timing leads to lower risk of DM deserves future exploration.

SUBMITTER: Yan B

PROVIDER: S-EPMC6853404 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Association Between Late Bedtime and Diabetes Mellitus: A Large Community-Based Study.

Yan Bin B Fan Yajuan Y Zhao Binbin B He Xiaoyan X Yang Jian J Chen Ce C Ma Xiancang X

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 20191101 11

<h4>Study objectives</h4>The aim of this study was to investigate the association of bedtime with the prevalence of diabetes mellitus (DM) based on a large community-based population.<h4>Methods</h4>In total, 5,420 participants (2,574 males and 2,846 females; aged 63.5 ± 11.0 years) from the Sleep Heart Health Study database were selected in this study. Sleep habit was recorded based on a questionnaire administered to patients upon recruitment. Bedtime was categorized as 11:00 pm and before, 11: ...[more]

PMID: 31739852

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Project description:BACKGROUND:There is increasing evidence that the lung is a target organ of diabetes. This study aimed to examine in detail the association between diabetes mellitus and pulmonary function using a national cohort. We also aimed to explore the non-linear association between pulmonary function and blood glucose, insulin resistance, and C-reactive protein (CRP). METHODS:A total of 30,442 participants from the National Health and Nutrition Examination Survey from the period between 2007 and 2012 were included. The cross-sectional association between diabetes mellitus and pulmonary function was assessed using multiple linear regression. Where there was evidence of non-linearity, we applied a restricted cubic spline with three knots to explore the non-linear association. Partial mediation analysis was performed to evaluate the underlying mechanism. All analyses were weighted to represent the US population and to account for the intricate survey design. RESULTS:A total of 8584 people were included in the final study population. We found that diabetes was significantly associated with reduced forced expiratory volume in one second (FEV1) and forced vital capacity. We further found L-shaped associations between hemoglobin A1c (HbA1c) and pulmonary function. There was a negative association between HbA1c and FEV1 in diabetes participants with good glucose control (HbA1c?<?7.0%), but not in patients with poor glucose control. A non-linear association was also found with fasting plasma glucose, 2 h-plasma glucose after oral glucose tolerance test, insulin resistance, and CRP. Finally, we found that diabetes duration did not affect pulmonary function, and the deleterious effect of diabetes on pulmonary function was mediated by hyperglycemia, insulin resistance, low-grade chronic inflammation (CRP), and obesity. CONCLUSIONS:Diabetes mellitus is non-linearly associated with pulmonary function. Our finding of a negative association between HbA1c and FEV1 in diabetes patients with good glucose control but not in patients with poor glucose control indicates that a stricter glycemic target should be applied to diabetic patients to improve pulmonary function. Given, the cross-sectional nature of this research, a longitudinal study is still needed to validate our findings.

Project description:OBJECTIVES:To investigate the association between late-life blood pressure and the incidence of cognitive impairment in older adults. DESIGN:Prospective cohort study. SETTING:Community-living older adults from 22 provinces in China. PARTICIPANTS:We included 12,281 cognitively normal [Mini-Mental State Examination (MMSE) ? 24] older adults (median age: 81 years) from the Chinese Longitudinal Healthy Longevity Survey. Eligible participants must have baseline blood pressure data and have 1 or more follow-up cognitive assessments. MEASUREMENTS:Baseline systolic (SBP) and diastolic blood pressure (DBP) were measured by trained internists. Cognitive function was evaluated by MMSE. We considered mild/moderate/severe cognitive impairment (MMSE <24, and MMSE decline ?3) as the primary outcome. RESULTS:The participants with hypertension had a significantly higher risk of mild/moderate/severe cognitive impairment (hazard ratio [HR] 1.17, 95% confidence interval [CI] 1.10-1.24). Overall, the associations with cognitive impairment seem to be hockey stick-shaped for SBP and linear for DBP, though the estimated effects for low SBP/DBP were less precise. High SBP was associated with a gradual increase in the risk of mild/moderate/severe cognitive impairment (P trend < .001). Compared with SBP 120 to 129 mmHg, the adjusted HR was 1.17 (95% CI 1.07-1.29) for SBP 130 to 139 mmHg, increased to 1.54 (95% CI 1.35-1.75) for SBP ?180 mmHg. Analyses for high DBP showed the same increasing pattern, with an adjusted HR of 1.09 (95% CI 1.01-1.18) for DBP 90 to 99 mmHg and 1.19 (95% CI 1.02-1.38) for DBP ?110 mmHg, as compared with DBP 70 to 79 mmHg. CONCLUSION:Late-life high blood pressure was independently associated with cognitive impairment in cognitively normal Chinese older adults. Prevention and management of high blood pressure may have substantial benefits for cognition among older adults in view of the high prevalence of hypertension in this rapidly growing population.

Dataset Information

Association Between Late Bedtime and Diabetes Mellitus: A Large Community-Based Study.

Publications

Association Between Late Bedtime and Diabetes Mellitus: A Large Community-Based Study.

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