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VulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

ABSTRACT:

Motivation

Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.

Results

vulcanSpot is a novel computational approach implemented to expand the therapeutic options in cancer beyond known-driver genes unlocking alternative ways to target undruggable genes. The method integrates genome-wide information provided by massive screening experiments to detect genetic vulnerabilities associated to tumors. Then, vulcanSpot prioritizes drugs to target cancer-specific gene dependencies using a weighted scoring system based on well known drug-gene relationships and drug repositioning strategies.

Availability and implementation

http://www.vulcanspot.org.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Perales-Paton J

PROVIDER: S-EPMC6853644 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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vulcanSpot: a tool to prioritize therapeutic vulnerabilities in cancer.

Perales-Patón Javier J Di Domenico Tomás T Fustero-Torre Coral C Piñeiro-Yáñez Elena E Carretero-Puche Carlos C Tejero Héctor H Valencia Alfonso A Gómez-López Gonzalo G Al-Shahrour Fátima F

Bioinformatics (Oxford, England) 20191101 22

<h4>Motivation</h4>Genetic alterations lead to tumor progression and cell survival but also uncover cancer-specific vulnerabilities on gene dependencies that can be therapeutically exploited.<h4>Results</h4>vulcanSpot is a novel computational approach implemented to expand the therapeutic options in cancer beyond known-driver genes unlocking alternative ways to target undruggable genes. The method integrates genome-wide information provided by massive screening experiments to detect genetic vuln ...[more]

PMID: 31173067

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