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Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes.

ABSTRACT: A phthaloyl-protected aminooxymethyl-C-2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles.

SUBMITTER: Maity SK

PROVIDER: S-EPMC6854833 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Synthesis of Organometallic Oligonucleotides through Oximation with Metalated Benzaldehydes.

Maity Sajal Kumar SK Lönnberg Tuomas A TA

ACS omega 20191101 20

A phthaloyl-protected aminooxymethyl-<i>C</i>-2'-deoxyriboside building block has been prepared and incorporated in the middle of an oligodeoxyribonucleotide. Removal of the phthaloyl protection followed by on-support oximation with either mercurated or palladated benzaldehydes yielded oligonucleotides bearing the respective benzaldoxime metallacycles. ...[more]

PMID: 31737842

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