Ontology highlight
ABSTRACT:
SUBMITTER: Muguruma K
PROVIDER: S-EPMC6855313 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Muguruma Kyohei K Ito Mayu M Fukuda Akane A Kishimoto Satoshi S Taguchi Akihiro A Takayama Kentaro K Taniguchi Atsuhiko A Ito Yuji Y Hayashi Yoshio Y
MedChemComm 20190801 10
Currently, IgG-binding peptides are widely utilized as a research tool, as molecules that guide substrates to the Fc site for site-selective antibody modification, leading to preparation of a homogeneous antibody-drug conjugate. In this study, a structure-activity relationship study of an IgG-binding peptide, 15-IgBP, that is focused on its C-terminal His residue was performed in an attempt to create more potent peptides. A peptide with a substitution of His17 by 2-pyridylalanine (2-Pya) showed ...[more]