Ontology highlight
ABSTRACT:
SUBMITTER: Robinson AM
PROVIDER: S-EPMC6856201 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Robinson Anthony M AM Rathore Richa R Redlich Nathan J NJ Adkins Douglas R DR VanArsdale Todd T Van Tine Brian A BA Michel Loren S LS
Cell death & disease 20191114 11
The loss of p16 is a signature event in Human Papilloma Virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) that leads to increased Cyclin Dependent Kinase 4/6 (CDK) signaling. Palbociclib, a CDK4/6 inhibitor, is active for the treatment of a subset of HNSCC. In this study, we analyzed patient response data from a phase I clinical trial of palbociclib in HNSCC and observed an association between prior cisplatin exposure and CDK inhibitor resistance. We studied the effects of palbo ...[more]