Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3K?.
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ABSTRACT:
SUBMITTER: Lajqi T
PROVIDER: S-EPMC6856213 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Memory-Like Inflammatory Responses of Microglia to Rising Doses of LPS: Key Role of PI3Kγ.
Lajqi Trim T Lang Guang-Ping GP Haas Fabienne F Williams David L DL Hudalla Hannes H Bauer Michael M Groth Marco M Wetzker Reinhard R Bauer Reinhard R
Frontiers in immunology 20191108
Trained immunity and immune tolerance have been identified as long-term response patterns of the innate immune system. The causes of these opposing reactions remain elusive. Here, we report about differential inflammatory responses of microglial cells derived from neonatal mouse brain to increasing doses of the endotoxin LPS. Prolonged priming with ultra-low LPS doses provokes trained immunity, i.e., increased production of pro-inflammatory mediators in comparison to the unprimed control. In con ...[more]
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