Ontology highlight
ABSTRACT:
SUBMITTER: Manina G
PROVIDER: S-EPMC6856624 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Manina Giulia G Griego Anna A Singh Lalit Kumar LK McKinney John D JD Dhar Neeraj N
The EMBO journal 20191004 22
Clonal microbial populations are inherently heterogeneous, and this diversification is often considered as an adaptation strategy. In clinical infections, phenotypic diversity is found to be associated with drug tolerance, which in turn could evolve into genetic resistance. Mycobacterium tuberculosis, which ranks among the top ten causes of mortality with high incidence of drug-resistant infections, exhibits considerable phenotypic diversity. In this study, we quantitatively analyze the cellular ...[more]