Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6856730 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells.
Li Ling L Hua Liang L Fan Huihui H He Yu Y Xu Wanfu W Zhang Lin L Yang Jie J Deng Fan F Zeng Fangyin F
Journal of Cancer 20191019 25
Protein kinase D (PKD) has been implicated in cancer cell survival, proliferation, migration and angiogenesis. However, it is still unknown whether PKD regulates cell proliferation through lipid metabolism in cancer cells. Here we report a novel function of PKD3, a member of PKD family, in regulating of prostate cancer cell proliferation by modulation of SREBP1-mediated <i>de novo</i> lipogenesis. We show that silencing of PKD3 significantly reduces lipid content and expression of the lipogenic ...[more]
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