Ontology highlight
ABSTRACT:
SUBMITTER: Yang XH
PROVIDER: S-EPMC6857534 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20170127 5
We communicate a strategy for the hydrofunctionalization of 1,3-dienes via Rh-hydride catalysis. Conjugated dienes are coupled to nucleophiles to demonstrate the feasibility of novel C-C, C-O, C-S, and C-N bond forming processes. In the presence of a chiral JoSPOphos ligand, hydroamination generates chiral allylic amines with high regio- and enantioselectivity. Tuning both the pK<sub>a</sub> and steric properties of an acid-additive is critical for enantiocontrol. ...[more]