Ontology highlight
ABSTRACT:
SUBMITTER: Kaya KD
PROVIDER: S-EPMC6857775 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kaya Koray D KD Chen Holly Y HY Brooks Matthew J MJ Kelley Ryan A RA Shimada Hiroko H Nagashima Kunio K de Val Natalia N Drinnan Charles T CT Gieser Linn L Kruczek Kamil K Erceg Slaven S Li Tiansen T Lukovic Dunja D Adlakha Yogita K YK Welby Emily E Swaroop Anand A
Molecular vision 20191111
<h4>Purpose</h4>Retinal organoids generated from human pluripotent stem cells exhibit considerable variability during differentiation. Our goals are to assess developmental maturity of the neural retina in vitro and design improved protocols based on objective criteria.<h4>Methods</h4>We performed transcriptome analyses of developing retinal organoids from human embryonic and induced pluripotent stem cell lines and utilized multiple bioinformatic tools for comparative analysis. Immunohistochemis ...[more]