Ontology highlight
ABSTRACT:
SUBMITTER: Luo X
PROVIDER: S-EPMC6858065 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Luo Xiao X Zhao Weiyu W Li Bin B Zhang Xinfu X Zhang Chengxiang C Bratasz Anna A Deng Binbin B McComb David W DW Dong Yizhou Y
Nano research 20180512 10
Nanoparticles have been widely explored for combined therapeutic and diagnostic applications. For example, lipid-based nanoparticles have been used to encapsulate multiple types of agents and achieve multi-functions. Herein, we enabled a co-delivery of mRNA molecules and superparamagnetic iron oxide nanoparticles (SPIONs) by using an amino-ester lipid-like nanomaterial. An orthogonal experimental design was used to identify the optimal formulation. The optimal formulation, MPA-Ab-8 LLNs, not onl ...[more]