Myosin 1b is an actin depolymerase.
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ABSTRACT:
SUBMITTER: Pernier J
PROVIDER: S-EPMC6858320 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Myosin 1b is an actin depolymerase.
Pernier Julien J Kusters Remy R Bousquet Hugo H Lagny Thibaut T Morchain Antoine A Joanny Jean-François JF Bassereau Patricia P Coudrier Evelyne E
Nature communications 20191115 1
The regulation of actin dynamics is essential for various cellular processes. Former evidence suggests a correlation between the function of non-conventional myosin motors and actin dynamics. Here we investigate the contribution of myosin 1b to actin dynamics using sliding motility assays. We observe that sliding on myosin 1b immobilized or bound to a fluid bilayer enhances actin depolymerization at the barbed end, while sliding on myosin II, although 5 times faster, has no effect. This work rev ...[more]
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