Ontology highlight
ABSTRACT:
SUBMITTER: Alaoui MAE
PROVIDER: S-EPMC6859701 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Alaoui My Abdelaziz El MAE Fartah Souad El SE Alaoui Najwa N Fahime El Mostapha El EME Habsaoui Amar A
Bioinformation 20191012 9
It is of interest to elucidate the binding mode analysis of 18 sulphonated flavones in the non nucleoside inhibitory binding pocket of the HIV-1 reverse transcriptase (PDB ID: 1RTD). We further compared them with the known Non Nucleosidic Reverse Transcriptase Inhibitors (NNRTI) drug molecules such as delaviridine, nevirapine and etravirine. Molecular docking studies of sulphonated flavones were performed in the binding pocket of reverse transcriptase using the PatchDock server. The flavones hav ...[more]