Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC6859925 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Zhao Chunmei C Thompson Benjamin J BJ Chen Kelly K Gao Feng F Blouw Barbara B Marella Mathieu M Zimmerman Susan S Kimbler Trevor T Garrovillo Sheryl S Bahn Jesse J Huang Lei L Huang Zhongdong Z Shepard H Michael HM Rosengren Sanna S Thanos Christopher D CD Maneval Daniel C DC
Oncotarget 20191112 61
Hyaluronan accumulation in the tumor microenvironment is associated with poor prognosis in several solid human cancers. To understand the role of stromal hyaluronan in tumor progression, we engineered 3T3HAS3, a hyaluronan-producing fibroblast cell line, by lentiviral transduction of Balb/c 3T3 cells with the <i>human hyaluronan synthase 3</i> <i>(HAS3)</i> gene. 3T3HAS3 cells significantly enhanced tumor growth when co-grafted with MDA-MB-468 cells in nude mice. Immunohistochemical analysis of ...[more]