Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC6860919 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Liu Suyu S Guo Beibei B Yuan Ying Y
Journal of the American Statistical Association 20180628 523
Immunotherapy is an innovative treatment approach that stimulates a patient's immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dosefinding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity and efficacy. The objective is to identify the biologically optimal dose, defined as the dose ...[more]