Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.
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SUBMITTER: Ahola-Olli AV
PROVIDER: S-EPMC6861432 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts.
Ahola-Olli Ari V AV Mustelin Linda L Kalimeri Maria M Kettunen Johannes J Jokelainen Jari J Auvinen Juha J Puukka Katri K Havulinna Aki S AS Lehtimäki Terho T Kähönen Mika M Juonala Markus M Keinänen-Kiukaanniemi Sirkka S Salomaa Veikko V Perola Markus M Järvelin Marjo-Riitta MR Ala-Korpela Mika M Raitakari Olli O Würtz Peter P
Diabetologia 20191004 12
<h4>Aims/hypothesis</h4>Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case-control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults.<h4>Methods</h4>NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24-45 years). Associati ...[more]
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